Developmental NeuroToxicity Data Integration and Visualization Enabling Resource (DNT-DIVER)

Logo: a zebrafish, neurons firing, data and charts

Research shows that a child’s developing nervous system is far more vulnerable to chemical exposures than an adult nervous system. Recent increases in the rise of neurodevelopmental disorders such as attention deficit hyperactivity disorder (ADHD), dyslexia, and autism spectrum disorder have prompted scientific interest in the potential contribution of environment toxicants to these disorders.

Traditional animal, or in vivo, studies provide important information about developmental neurotoxicity (DNT) but they are time and resource intensive. NTP has also developed more rapid screening tools that use human cell-based, or in vitro, assays, as well as alternate animal models such as zebrafish and planaria to identify toxicants with potential for DNT. Multiple tests, or assays, are often required to represent the complexity of the developing nervous system, but that can make it challenging to compare and summarize results.

NTP designed the Developmental NeuroToxicity Data Integration and Visualization Enabling Resource (DNT-DIVER) to analyze, compare, and visualize multiple DNT assays in an interactive web-application.

Within DNT-DIVER, comparisons are organized on different tabs including experimental design summary, quality control, chemical-specific concentration response curves, ranking of chemical toxicity per lab/assay, and comparison of results across assays. We also provide downloadable resources including raw and final data, along with the NTP Chemical Library (Microsoft Excel ) that was tested by collaborators in their respective models.

Suggestions?

We are currently refining assays, analyses, and visualizations, and would appreciate your input! Please direct questions or suggestions to Mamta Behl.